Journal article
Yinan Wan, Alexandra D. Almeida, S. Rulands, Naima Chalour, Leila Mureşan, Yunmin Wu, B. Simons, Jie He, W. Harris
Development, 2016
Development, 2016
DOI:
10.1242/dev.133314
DOI
PubMed
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APA
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Wan, Y., Almeida, A. D., Rulands, S., Chalour, N., Mureşan, L., Wu, Y., … Harris, W. (2016). The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue. Development. https://doi.org/10.1242/dev.133314
Chicago/Turabian
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Wan, Yinan, Alexandra D. Almeida, S. Rulands, Naima Chalour, Leila Mureşan, Yunmin Wu, B. Simons, Jie He, and W. Harris. “The Ciliary Marginal Zone of the Zebrafish Retina: Clonal and Time-Lapse Analysis of a Continuously Growing Tissue.” Development (2016).
MLA
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Wan, Yinan, et al. “The Ciliary Marginal Zone of the Zebrafish Retina: Clonal and Time-Lapse Analysis of a Continuously Growing Tissue.” Development, 2016, doi:10.1242/dev.133314.
BibTeX Click to copy
@article{yinan2016a,
title = {The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue},
year = {2016},
journal = {Development},
doi = {10.1242/dev.133314},
author = {Wan, Yinan and Almeida, Alexandra D. and Rulands, S. and Chalour, Naima and Mureşan, Leila and Wu, Yunmin and Simons, B. and He, Jie and Harris, W.}
}
Abstract
Clonal analysis is helping us understand the dynamics of cell replacement in homeostatic adult tissues (Simons and Clevers, 2011). Such an analysis, however, has not yet been achieved for continuously growing adult tissues, but is essential if we wish to understand the architecture of adult organs. The retinas of lower vertebrates grow throughout life from retinal stem cells (RSCs) and retinal progenitor cells (RPCs) at the rim of the retina, called the ciliary marginal zone (CMZ). Here, we show that RSCs reside in a niche at the extreme periphery of the CMZ and divide asymmetrically along a radial (peripheral to central) axis, leaving one daughter in the peripheral RSC niche and the other more central where it becomes an RPC. We also show that RPCs of the CMZ have clonal sizes and compositions that are statistically similar to progenitor cells of the embryonic retina and fit the same stochastic model of proliferation. These results link embryonic and postembryonic cell behaviour, and help to explain the constancy of tissue architecture that has been generated over a lifetime. Summary: A quantitative study of cell proliferation and fate choice in the zebrafish retina - a continuously growing neural tissue - reveals key features of late retinal neurogenesis.